The president, 80, was walking across the stage after shaking hands with graduates when he tripped over a black sandbag and fell to the ground. He was quickly helped to his feet by Secret Service agents and an Air Force officer.
The president appeared to be unhurt and continued to stand and greet people for the remainder of the ceremony. He later boarded Air Force One without incident.
The White House said the president was "fine" and that the fall was due to a "snag" on the stage.
The incident drew immediate attention on social media, with some users expressing concern for the president's health. Others joked about the fall, with one user comparing it to a scene from the movie "The Matrix."
The president's fall comes at a time when he is facing increasing scrutiny over his age and health. Biden is the oldest person to ever serve as president of the United States.