Iran's Supreme Leader Ayatollah Ali Khamenei has declined the possibility of negotiations with the United States regarding its nuclear program, following the delivery of a letter from President Donald Trump.

Khamenei stated he had not personally reviewed the letter, reportedly conveyed by a representative from the United Arab Emirates, but characterized it as a "deception of public opinion."

Trump's correspondence, sent last week, purportedly suggested discussions aimed at reaching an agreement to prevent Iran from acquiring nuclear weapons and to avert potential military action.

Khamenei, however, critiqued the US's reliability in negotiations, recalling Trump's withdrawal from the 2015 Iranian nuclear agreement during his first term.

He questioned the merit of engaging in talks, stating, "When we know they won't honour it, what's the point of negotiating?"

Reiterating Iran's position, Khamenei asserted the nation does not seek nuclear weapons but emphasized that any military strikes on Iranian nuclear facilities would result in a "decisive and certain" response.

He asserted that the repercussions of such actions would substantially affect the United States.

The context of Khamenei's remarks is rooted in the historical agreement made in 2015 between Iran and six world powers: China, France, Germany, Russia, the United Kingdom, and the United States.

This accord was designed to regulate Iran's nuclear activities in exchange for sanctions relief and permitted monitoring by the International Atomic Energy Agency (IAEA).

However, in 2018, Trump exited the agreement, reinstating stringent economic sanctions while criticizing the deal as inadequate in halting Iran's path towards nuclear weaponization.

In response to the US's withdrawal and the reimposition of sanctions, Iran began to breach the terms of the original agreement.

The IAEA reported last month that Iran had amassed nearly 275 kg (606 lb) of uranium enriched to 60% purity, a level close to weapons-grade material which could, if enriched to 90%, produce sufficient fissile material for up to six nuclear bombs.

Both the United States and Israel maintain a hardline stance, asserting that Iran will never be allowed to obtain nuclear capabilities.

Israel, in particular, has threatened preemptive strikes against Iranian nuclear facilities.

Last year, Israeli military actions were reported to have targeted parts of Iran’s nuclear program in response to an Iranian missile attack.

In a televised interview aired on Friday, Trump reiterated the dual approaches available for addressing Iran, stating, "There are two ways Iran can be handled: militarily, or you make a deal." Trump expressed his preference for diplomacy, mentioning his letter to Iran encouraging negotiation, while also warning of severe consequences should military action be necessary.

The White House has not detailed the contents of Trump’s letter; Iranian officials confirmed that it was received by Foreign Minister Abbas Araqchi through UAE presidential adviser Anwar Gargash.

Despite Khamenei's outright rejection of US negotiations, Iran's mission to the United Nations indicated openness to discussions if focused on alleviating concerns regarding Iran's nuclear endeavors.

Araqchi also noted ongoing nuclear discussions with the United Kingdom, France, and Germany.

Meanwhile, the Chinese foreign ministry announced that a trilateral meeting addressing the "Iranian nuclear issue" would take place in Beijing, involving China, Russia, and Iran.